次黄嘌呤 - 鸟嘌呤磷酸核糖转移酶突变型胶质瘤细胞：单胺氧化酶活性降低。
Hypoxanthine-guanine phosphoribosyltransferase mutant glioma cells: diminished monamine oxidase activity.
作者信息
Skaper S D, Seegmiller J E
出版信息
Science. 1976 Dec 10;194(4270):1171-3. doi: 10.1126/science.996547.
PMID:996547
Abstract
A defective capability of cultured rat glioma cells to reutilize purine bases (hypoxanthine-guanine phosphoribosyltransferase deficiency) was associated with a reduced capacity to oxidatively deaminate serotonin and tryptamine. The mutant glioma cells were also more sensitive to the cytotoxic effects of serotonin than were normal cells
摘要
培养的大鼠胶质瘤细胞再利用嘌呤碱的能力缺陷（次黄嘌呤 - 鸟嘌呤磷酸核糖转移酶缺乏）与氧化脱氨血清素和色胺的能力降低有关。与正常细胞相比，突变的胶质瘤细胞对血清素的细胞毒性作用也更敏感。
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