临床病理变量及p53过表达作为结直肠癌血行复发的联合预后指标
Clinicopathological variables and p53 overexpression as a combined prognosticator for hematogenic recurrence in colorectal cancer.
作者信息
Yamamura T, Matsuzaki H, Suda T, Ozasa T, Tsukikawa S, Yamaguchi S
机构信息
Department of Surgery, St. Marianna University School of Medicine, Toyoko Hospital, Kawasaki, Japan.
出版信息
J Surg Oncol. 1999 Jan;70(1):1-5. doi: 10.1002/(sici)1096-9098(199901)70:1<1::aid-jso1>3.0.co;2-e.
BACKGROUND AND OBJECTIVE
Precise evaluation of the prognostic factors for hematogenic recurrence after resection for colorectal cancer is important not only for the prediction of patient outcome but also for the determination of adjuvant therapy. The purpose of the current study was to elucidate the clinical significance of using clinicopathological variables in combination with p53 expression as a prognosticator for hematogenic recurrence.
METHODS
One hundred forty-two patients with colorectal cancer were examined. The expression of p53 was determined by immunohistochemical staining.
RESULTS
Eighteen (60%) of the 30 patients who were positive for both p53 overexpression and lymph node metastasis, 13 (41%) of the 32 patients who were positive for p53 and venous invasion, and 13 (39%) of the 33 patients who were positive for p53 and carcinoembryonic antigen (CEA) developed hematogenic recurrence.
CONCLUSIONS
The combination of p53 overexpression and lymph node metastasis was an excellent prognostic indicator for hematogenic recurrence in colorectal cancer.
背景与目的
精确评估结直肠癌切除术后血行转移复发的预后因素不仅对于预测患者预后很重要，而且对于确定辅助治疗也很重要。本研究的目的是阐明将临床病理变量与p53表达相结合作为血行转移复发预后指标的临床意义。
方法
对142例结直肠癌患者进行了检查。通过免疫组织化学染色确定p53的表达。
结果
p53过表达和淋巴结转移均为阳性的30例患者中有18例（60%）发生血行转移复发，p53阳性且有静脉侵犯的32例患者中有13例（41%）发生血行转移复发，p53阳性且癌胚抗原（CEA）阳性的33例患者中有13例（39%）发生血行转移复发。
结论
p53过表达与淋巴结转移相结合是结直肠癌血行转移复发的一个良好预后指标。
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