Alteration in the uptake and storage of cardiac noradrenaline in spontaneously hypertensive rats.

Uptake and storage of noradrenaline administered to Spontaneously hypertensive rate (SHR) (14) was significantly reduced compared with normotensive Wister rats (NR). Initial uptake of noradrenaline at 10 minutes was only 19 per cent less in SHR than in NR. However, 60 minutes following the administration of noradrenaline, its concentration in the heart of SHR was 60 per cent less than that in NR. Noradrenaline administered to NR disappeared from the heart in 10 hours, and that from SHR in 5 hours only.