Snedden W, Parker R B
Biomed Mass Spectrom. 1976 Dec;3(6):295-8. doi: 10.1002/bms.1200030608.
The concentration of oestrone, oestradiol and progesterone in ovarian tissue have been determined directly by quantitative high resolution mass fragmentography without the necessity of extraction or purification. The changes in the levels of these steroids in the ovary throughout a 28 day period correlate well with those measured in plasma and also with those of the corresponding metabolites excreted in urine. Some benign ovarian tumours (cysts) have been shown to contain abnormally large amounts of progesterone.
通过定量高分辨率质量碎片分析法直接测定了卵巢组织中雌酮、雌二醇和孕酮的浓度，无需进行提取或纯化。在整个28天的周期内，卵巢中这些甾体激素水平的变化与血浆中测得的变化以及尿液中排泄的相应代谢产物的变化密切相关。一些良性卵巢肿瘤（囊肿）已被证明含有异常大量的孕酮。
