氨氯地平对大鼠离体尾部附睾中钠依赖性液体重吸收的抑制作用。
Inhibition by amiloride of sodium-dependent fluid reabsorption in the rat isolated caudal epididymis.
作者信息
Wong P Y, Yeung C H
出版信息
Br J Pharmacol. 1976 Dec;58(4):529-31. doi: 10.1111/j.1476-5381.1976.tb08620.x.
Abstract
The rate of fluid reabsorption was studied in the rat isolated caudal epididymal sac in vitro. 2 Part of the fluid reabsorption was found to be dependent on intraluminal Na+. Amiloride (0.1 mM) completely inhibited this component of fluid reabsorption. 3 The log dose-inhibition curve to amiloride was sigmoid and the IC50 value was found to be 1.6 muM.
摘要
在体外对大鼠分离的尾部附睾囊的液体重吸收速率进行了研究。发现部分液体重吸收依赖于管腔内的钠离子。氨氯吡咪（0.1 mM）完全抑制了这部分液体重吸收。氨氯吡咪的对数剂量抑制曲线呈S形，IC50值为1.6 μM。
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