Klein David M, Cherrington Nathan J
University of Arizona; Department of Pharmacology and Toxicology ; Tucson, AZ, US.
Spermatogenesis. 2015 Jan 7;4(2):e979653. doi: 10.4161/21565562.2014.979653. eCollection 2014 May-Aug.
Transporters have a huge impact on the toxicology and pharmacological effects of xenobiotics in addition to being implicated in several diseases. While these important proteins have been well studied in organs such as the kidney or liver, characterization of transporters in the testis is still in the early stages. Knowledge of transporter function may greatly advance the field's understanding of the physiological and toxicological processes that occur in the testis. Several foundational studies involving both organic and inorganic transporters have been critical in furthering our understanding of how the testis interacts with endogenous and xenobiotic compounds. This review provides an overview of how transporters function, their clinical significance, and highlights what is known for many of the important transporters in the testis.
转运蛋白除了与多种疾病有关外，还对异生物素的毒理学和药理作用有巨大影响。虽然这些重要蛋白质在肾脏或肝脏等器官中已得到充分研究，但睾丸中转运蛋白的特征描述仍处于早期阶段。转运蛋白功能的知识可能会极大地推动该领域对睾丸中发生的生理和毒理学过程的理解。几项涉及有机和无机转运蛋白的基础研究对于加深我们对睾丸如何与内源性和外源性化合物相互作用的理解至关重要。本综述概述了转运蛋白的功能、它们的临床意义，并重点介绍了睾丸中许多重要转运蛋白的已知情况。
