Evans J A, Lambert M B, Miller J
Br J Sports Med. 1976 Oct;10(3):124-7. doi: 10.1136/bjsm.10.3.124.
The anti-inflammatory drug Ibuprofen [(+/-)-2-(p-isobutylphenyl) propionic acid] was estimated in the blood and urine of a horse using gas-liquid chromatography of the silylated derivative. Levels of the drug in the two body fluids were measured over a period of about 24 hours after administering a 12 gm dose of Ibuprofen. Plasma peak levels were observed within 30 to 60 min, and the drug was no longer detectable in the plasma by 8 hr. Urinary peak levels were observed 200 to 300 min after dosing, and the drug was no longer detectable in the urine by about 28 hr. It was observed that only 2% to 6% of the free unchanged drug was excreted in the urine.
使用硅烷化衍生物的气液色谱法对一匹马的血液和尿液中的抗炎药物布洛芬[（±）-2-（对异丁基苯基）丙酸]进行了测定。在给予12克剂量的布洛芬后约24小时内，测量了两种体液中该药物的水平。血浆峰值水平在30至60分钟内观察到，8小时后血浆中不再能检测到该药物。给药后200至300分钟观察到尿峰值水平，约28小时后尿液中不再能检测到该药物。观察到仅2%至6%的游离未变化药物从尿液中排出。
