Smith C B, Smith D A
Calcif Tissue Res. 1976 Dec 22;22(2):219-26. doi: 10.1007/BF02010360.
Evidence relating to the existence of crystalline bone mineral in vivo is considered, and bone apatite crystal structure investigated using an x-ray powder diffraction technique. Specimens of femoral compacta excised post-mortem from male and female subjects ranging from 3 1/2 years to 87 years of age have been studied. Values of the ratio c/a of bone apatite crystal cell axes for females are significantly higher (p less than 0.05) than for males. Moreover, significant change of c/a with age is observed for males (p = 0.0005) but not for females (p = 0.30). Differences in c/a are interpreted as indicating substitution of constituent ions in the bone apatite crystals.
考虑了与体内结晶骨矿物质存在相关的证据，并使用X射线粉末衍射技术研究了骨磷灰石晶体结构。对年龄在3.5岁至87岁之间的男性和女性受试者死后切除的股骨密质标本进行了研究。女性骨磷灰石晶胞轴的c/a比值显著高于男性（p<0.05）。此外，观察到男性的c/a随年龄有显著变化（p = 0.0005），而女性则没有（p = 0.30）。c/a的差异被解释为表明骨磷灰石晶体中组成离子的替代。
