Corr P B, Pearle D L, Hinton J R, Roberts W C, Gillis R A
Circ Res. 1976 Dec;39(6):840-7. doi: 10.1161/01.res.39.6.840.
The influence of site of acute myocardial infarction on heart rate, blood pressure, cardiac output, total peripheral resistance (TPR), cardiac rhythm, and mortality was determined in 58 anesthetized cats by occlusion of either the left anterior descending (LAD), left circumflex or right coronary artery. LAD occlusion resulted in immediate decrease in cardiac output, heart rate, and blood pressure, an increase in TPR, and cardiac rhythm changes including premature ventricular beats, ventricular tachycardia, and occasionally ventricular fibrillation. The decrease in cardiac output and increase in TPR persisted in the cats surviving a ventricular arrhythmia. In contrast, right coronary occlusion resulted in a considerably smaller decrease in cardiac output. TPR did not increase, atrioventricular condition disturbances were common, and sinus bradycardia and hypotension persisted in the cats recovering from an arrhythmia. Left circumflex ligation resulted in cardiovascular changes intermediate between those produced by occlusion of the LAD or the right coronary artery. Mortality was similar in each of the three groups. We studied the coronary artery anatomy in 12 cats. In 10, the blood supply to the sinus node was from the right coronary artery and in 2, from the left circumflex coronary artery. The atrioventricular node artery arose from the right in 9 cats, and from the left circumflex in 3. The right coronary artery was dominant in 9 cats and the left in 3. In conclusion, the site of experimental coronary occlusion in cats is a major determinant of the hemodynamic and cardiac rhythm changes occurring after acute myocardial infarction. The cardiovascular responses evoked by ligation are related in part to the anatomical distribution of the occluded artery.
通过阻断左前降支（LAD）、左旋支或右冠状动脉，在58只麻醉猫中确定急性心肌梗死部位对心率、血压、心输出量、总外周阻力（TPR）、心律和死亡率的影响。LAD阻断导致心输出量、心率和血压立即下降，TPR升高，以及心律变化，包括室性早搏、室性心动过速，偶尔还有心室颤动。在心律失常存活的猫中，心输出量下降和TPR升高持续存在。相比之下，右冠状动脉阻断导致心输出量下降幅度小得多。TPR没有升高，房室传导障碍常见，从心律失常恢复的猫中窦性心动过缓和低血压持续存在。左旋支结扎导致的心血管变化介于LAD或右冠状动脉阻断所产生的变化之间。三组中的死亡率相似。我们研究了12只猫的冠状动脉解剖结构。10只猫的窦房结血液供应来自右冠状动脉，2只来自左旋支冠状动脉。9只猫的房室结动脉起源于右侧，3只起源于左旋支。9只猫的右冠状动脉占优势，3只猫的左冠状动脉占优势。总之，猫实验性冠状动脉阻断的部位是急性心肌梗死后发生的血流动力学和心律变化的主要决定因素。结扎引起的心血管反应部分与闭塞动脉的解剖分布有关。
