Schley G, Anlauf M, Bock K D
Dtsch Med Wochenschr. 1976 Dec 24;101(52):1901-7. doi: 10.1055/s-0028-1104352.
Out of 14 women with acute intermittent porphyria seven were treated for an average of five years with ovulation inhibitors. In another two cases a bilateral surgical oophorectomy and a radiotherapeutic castration were performed. Five untreated women formed the control group. In contrast to the control group there were no further acute exacerbations in the group treated with oral contraceptives. The two patients with oophorectomy and irradiation castration died following multiple acute exacerbations. In four of the women treated with oral contraceptives the development of persistent, and in some cases severe, arterial hypertension was observed. The pathogenesis cannot be explained.
在14例急性间歇性卟啉病女性患者中，7例接受了平均5年的排卵抑制剂治疗。另外2例分别进行了双侧手术卵巢切除术和放射去势术。5例未接受治疗的女性组成了对照组。与对照组相比，口服避孕药治疗组未出现进一步的急性发作。接受卵巢切除术和放射去势术的2例患者在多次急性发作后死亡。在接受口服避孕药治疗的4例女性中，观察到持续性动脉高血压的发生，有些病例还很严重。其发病机制尚无法解释。
