Clarkson T B, Shively C A, Morgan T M, Koritnik D R, Adams M R, Kaplan J R
Arteriosclerosis Research Center, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina.
Obstet Gynecol. 1990 Feb;75(2):217-22.
Studies of both human and nonhuman primates show an inverse relationship between high-density lipoprotein (HDL) cholesterol concentrations and coronary artery atherosclerosis. For this reason, there has been concern that the HDL cholesterol-lowering effect of oral contraceptives might exacerbate coronary artery atherosclerosis. We studied three groups of adult female cynomolgus macaques fed a moderately atherogenic diet: a control group, a group given ethinyl estradiol and norgestrel, and another group given ethinyl estradiol and ethynodiol diacetate. Norgestrel and ethynodiol diacetate, co-administered with ethinyl estradiol, lowered the plasma concentrations of HDL cholesterol. However, the extent of coronary artery atherosclerosis was lessened by both contraceptives, especially among females at high risk based on their plasma lipid profiles.
对人类和非人类灵长类动物的研究表明，高密度脂蛋白（HDL）胆固醇浓度与冠状动脉粥样硬化之间存在负相关关系。因此，人们担心口服避孕药降低HDL胆固醇的作用可能会加剧冠状动脉粥样硬化。我们研究了三组成年雌性食蟹猴，它们食用中度致动脉粥样化饮食：一组为对照组，一组给予炔雌醇和炔诺酮，另一组给予炔雌醇和双醋炔诺醇。与炔雌醇共同给药时，炔诺酮和双醋炔诺醇降低了HDL胆固醇的血浆浓度。然而，两种避孕药都减轻了冠状动脉粥样硬化的程度，尤其是在根据血脂谱处于高风险的雌性动物中。
