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[舒必利与精神代偿失调]

[Sulpiride and psychic decompensation].

作者信息

Pelc I

出版信息

Encephale. 1976;2(4):349-61.

PMID:1001243
Abstract

The use of sulpirid in psychiatry allows to delineate three types of activity of this compound which originality consists most in this triple association: neuroleptic activity, as well as anticonfusional and antidepressive. The psychodynamic and phenomenological evaluation of patients receiving a sulpirid treatment, has led us to consider the process of "psychic decompensation" as a target variable particularly sensitive to the action of this psychotropic drug. This process can be found in various pathological states--acute delirious states, depressive episodes, anxiety, autism, stress situation--where sulpirid acts, beside its specific thymoanaleptic or neuroleptic properties, through a "aspecific recompensation activity". This translates, psychopathologically, the action of sulpirid on the vegetative brain as well as the anti-stress properties of this psychrotropic drug, as verified in animal experiment.

摘要

舒必利在精神病学中的应用使我们能够界定该化合物的三种活性类型,其独特之处主要在于这种三重关联:抗精神病活性以及抗惊厥和抗抑郁活性。对接受舒必利治疗的患者进行的心理动力学和现象学评估,使我们将“精神失代偿”过程视为对这种精神药物作用特别敏感的目标变量。这一过程可见于各种病理状态——急性谵妄状态、抑郁发作、焦虑、自闭症、应激状态——在这些状态下,舒必利除了具有其特定的心境安定或抗精神病特性外,还通过“非特异性代偿活性”发挥作用。从心理病理学角度来看,这体现了舒必利对植物性神经系统的作用以及这种精神药物的抗应激特性,这在动物实验中得到了证实。

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