Krause W, Schwaebe P
Endokrinologie. 1976 Oct;68(1):22-6.
Male rats of the Wistar/Han strain are treated with ovine FSH, hCG or PMS in various doses for twelve days, beginning on the 1st, 12th, 24th or 36th day of life each. The determination of FSH in plasma by radioimmunoassay at the end of the treatment shows that all exogenous gonadotropins depress the FSH levels to immeasurable values. Plasma testosterone increases after application of hCG and PMS, not ovine FSH. To explain these findings a hypothalamic inhibition of the FSH release by a "short feedback" mechanism is discussed.
选用Wistar/Han品系的雄性大鼠，分别于出生后的第1天、第12天、第24天或第36天开始，用不同剂量的羊促卵泡素（FSH）、人绒毛膜促性腺激素（hCG）或孕马血清促性腺激素（PMS）处理12天。在处理结束时通过放射免疫测定法测定血浆中的FSH，结果显示所有外源性促性腺激素均将FSH水平降低至无法测量的值。应用hCG和PMS后血浆睾酮增加，而羊FSH则无此作用。为了解释这些发现，讨论了通过“短反馈”机制对下丘脑FSH释放的抑制作用。
