Plaa G L
Environ Health Perspect. 1976 Jun;15:39-46. doi: 10.1289/ehp.761539.
Liver function data are usually difficult to use in their original form when one wishes to compare the hepatotoxic properties of several chemical substances. However, procedures are available for the conversion of liver function data into quantal responses. These permit the elaboration of dose-response lines for the substances in question, the calculation of median effective doses and the statistical analysis of differences in liver-damaging potency. These same procedures can be utilized for estimating the relative hazard involved if one compares the liver-damaging potency to the median effective dose for some other pharmacologie parameter. Alterations in hepatic triglycerides, lipid peroxidation, and the activities of various hepatic enzymes can also be quantitiated in a dose-related manner. This permits the selection of equitoxic doses required for certain comparative studies and the selection of doses in chemical interaction studies. The quantitative problems involved in low-frequency adverse reactions and the difficulty these present in the detection of liver injury in laboratory animals are discussed.
当人们想要比较几种化学物质的肝毒性时，肝功能数据通常很难以其原始形式使用。然而，有一些方法可以将肝功能数据转化为定量反应。这些方法可以用来绘制相关物质的剂量-反应曲线，计算半数有效剂量，并对肝损伤效力的差异进行统计分析。如果将肝损伤效力与其他一些药理学参数的半数有效剂量进行比较，同样的方法也可用于估计相关的相对风险。肝甘油三酯、脂质过氧化以及各种肝酶活性的变化也可以以剂量相关的方式进行定量。这有助于在某些比较研究中选择等效毒性剂量，以及在化学相互作用研究中选择剂量。本文还讨论了低频不良反应中涉及的定量问题以及这些问题给实验动物肝损伤检测带来的困难。
