Rentsch H P, Ayer G, Valloton M, Ziegler W, Truniger B
Eur J Clin Invest. 1976 Nov 30;6(6):457-64. doi: 10.1111/j.1365-2362.1976.tb00543.x.
The haemodynamic effects of angiotensin II and noradrenaline were studied in the rat kidney. These pressors were given by intravenous infusion in stepwise increasing doses. Intrarenal haemodynamics were analyzed by the 133xenon washout technique, 85krypton autoradiography and silastic casting of the renal vascular tree. Angiotensin II induced significant changes in intrarenal haemodynamics before any changes in systemic blood pressure were detected. The decrease in mean renal blood flow (2.91 ml.min-1.g-1 in controls, 1.76 ml.min-1.g-1 in rats given 50 mug of angiotensin II.kg-1.h-1) reflects a reduction in component I blood flow rate (from 3.9 to 2.9 ml.min-1.g-1) as well as a decrease in the fraction of total renal blood flow supplied to component I of the washout curve (from 84% to 62%). With noradrenaline an increase in total renal resistance occurred simultaneously with the elevation of mean arterial blood pressure. The resulting reduction in mean renal blood flow (from 2.76 ml.min-1.g-1 in controls to 1.55 ml.min-1.g-1 in rats given 1000 mug of noradrenaline kg-1.h-1) reflects a decrease in component I blood flow rate with lower infusion rates and a drop in component I flow fraction (from 82% to 52%) whith higher doses. In contrast to canine kidneys, no evidence for a patchy cortical vasoconstriction was found in the rat. Using autoradiography it was possible to attribute component I to the renal cortex and subcortical area of the kidney.
在大鼠肾脏中研究了血管紧张素II和去甲肾上腺素的血流动力学效应。通过静脉输注逐步增加剂量给予这些升压药。采用133氙洗脱技术、85氪放射自显影术和肾血管树硅橡胶铸型分析肾内血流动力学。在检测到全身血压有任何变化之前，血管紧张素II就引起了肾内血流动力学的显著变化。平均肾血流量的减少（对照组为2.91 ml·min-1·g-1，给予50 μg血管紧张素II·kg-1·h-1的大鼠为1.76 ml·min-1·g-1）反映了I组分血流速率的降低（从3.9降至2.9 ml·min-1·g-1）以及洗脱曲线I组分所供应的肾总血流量比例的下降（从84%降至62%）。使用去甲肾上腺素时，肾总阻力增加的同时平均动脉血压升高。由此导致的平均肾血流量减少（从对照组的2.76 ml·min-1·g-1降至给予1000 μg去甲肾上腺素·kg-1·h-1的大鼠的1.55 ml·min-1·g-1）反映了较低输注速率时I组分血流速率的降低以及较高剂量时I组分血流分数的下降（从82%降至52%）。与犬肾不同，在大鼠中未发现皮质斑片状血管收缩的证据。通过放射自显影术有可能将I组分归因于肾皮质和肾皮质下区域。
