Hirose F, Watanabe H, Takeichi N, Naito Y, Inoue S
Gan. 1976 Jun;67(3):355-64.
Divided doses of 6,000 or 8,000 rad of X-ray were given to the gastric region of ICR/JCL female mice with immune atrophic gastritis produced by the injection with allogenic stomach antigen. The carcinogenic effect of X-rays for inducing gastric carcinoma was significantly increased by this method. Two points can be presented as its reason. First, the pyloric gland mucosa regenerating from injuries by immunization was exposed to the divided dose of X-rays. Second, the marked requirement of gastrin secretion attributable to severe injuries of parietal cell mass by immunization and local X-irradiation acted as a promoting factor on the induction of gastric carcinoma by X-ray for a long time through the trophic effects on the pyloric gland.
将6000或8000拉德的X射线分次照射到通过注射同种异体胃抗原产生免疫萎缩性胃炎的ICR/JCL雌性小鼠的胃部区域。通过这种方法，X射线诱导胃癌的致癌作用显著增强。其原因可归结为两点。第一，因免疫损伤而再生的幽门腺黏膜暴露于分次剂量的X射线下。第二，免疫和局部X射线照射导致壁细胞大量严重损伤，从而显著增加胃泌素分泌的需求，通过对幽门腺的营养作用，长期作为X射线诱导胃癌的促进因素。
