Belham C, Wu S, Avruch J
Diabetes Unit and Medical Services, Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA.
Curr Biol. 1999 Feb 11;9(3):R93-6. doi: 10.1016/s0960-9822(99)80058-x.
Phosphoinositide-dependent kinase 1 (PDK1) is at the hub of many signalling pathways, activating PKB and PKC isoenzymes, as well as p70 S6 kinase and perhaps PKA. PDK1 action is determined by colocalization with substrate and by target site availability, features that may enable it to operate in both resting and stimulated cells.
磷酸肌醇依赖性激酶1（PDK1）处于许多信号通路的核心位置，可激活蛋白激酶B（PKB）和蛋白激酶C（PKC）同工酶，以及p70 S6激酶，或许还能激活蛋白激酶A（PKA）。PDK1的作用取决于与底物的共定位以及靶位点的可用性，这些特性可能使其能够在静息细胞和受刺激细胞中发挥作用。
