Calamandrei G, Venerosi A, Branchi I, Chiarotti F, Verdina A, Bucci F, Alleva E
Section of Comparative Psychology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanità, Rome, Italy.
Neurotoxicol Teratol. 1999 Jan-Feb;21(1):29-40. doi: 10.1016/s0892-0362(98)00035-x.
Recent evidence has shown that perinatal administration of zidovudine (AZT) to HIV-infected mothers reduces the risk of maternal-infant transmission of the virus. Treatment of pregnant seropositive women with AZT is becoming a common medical practice, despite the paucity of information about the potential neurotoxic/behavioral-teratogenic effects of AZT on the developing organism. The aim of the present study is to evaluate in mice the short-, medium-, and long-term effects of prenatal exposure to AZT on neurobehavioral development. Pregnant mice were given 0.2, 0.4, and 2.0 mg/ml AZT in drinking water from day 10 of gestation to delivery. Offspring's viability was severely affected in the 2.0 mg/ml AZT group. Thus, behavioral analysis was carried out in offspring of 0.2 and 0.4 mg/ml AZT-treated females only. Some limited but significant alterations were found, such as stunted body weight, delayed appearance of the pole-grasping reflex, and a slight impairment in the acquisition phase of a passive avoidance response. Moreover, sexual differences in some items of the social behavior repertoire appeared to be affected by AZT treatment.
最近的证据表明，对感染艾滋病毒的母亲进行围产期齐多夫定（AZT）给药可降低母婴传播病毒的风险。尽管关于AZT对发育中的生物体潜在神经毒性/行为致畸作用的信息匮乏，但用AZT治疗血清反应阳性的孕妇正成为一种常见的医疗做法。本研究的目的是评估小鼠产前接触AZT对神经行为发育的短期、中期和长期影响。从妊娠第10天到分娩，给怀孕小鼠饮用含0.2、0.4和2.0mg/ml AZT的水。在2.0mg/ml AZT组中，后代的存活率受到严重影响。因此，仅在接受0.2和0.4mg/ml AZT治疗的雌性后代中进行行为分析。发现了一些有限但显著的变化，如体重发育迟缓、抓杆反射出现延迟，以及被动回避反应习得阶段的轻微受损。此外，社会行为库中某些项目的性别差异似乎受到AZT治疗的影响。
