Graves S, Holman B, Rossetti M, Estey C, Felder R
Medical Automation Research Center, Department of Pathology, University of Virginia, Charlottesville 22908, USA.
Clin Chim Acta. 1998 Dec;278(2):269-79. doi: 10.1016/s0009-8981(98)00152-1.
Laboratory automation systems (LAS) have been installed in over 22 sites across North America providing automation of many preanalytical and analytical tasks in clinical laboratories. Only a few laboratories have automated the analysis of citrated whole blood for the diagnosis of hemostasis disorders. The analysis of coagulation factors in citrated blood requires a large amount of labor in order to provide rapid turnaround; thus automation of this analytical process is attractive. Therefore, we have created an automated coagulation workstation using a systematic approach to automation design and engineering. First, we used discrete event simulation to calculate potential throughput and to identify possible bottlenecks for the proposed coagulation workcell. We then created a three-dimensional animated computer model of the workstation to simplify workstation design. Finally, we constructed a prototype workcell using a mobile robot, an articulated robotic arm, and a coagulation analytical system.
实验室自动化系统（LAS）已在北美22个以上的地点安装，实现了临床实验室许多分析前和分析任务的自动化。只有少数实验室实现了用于止血障碍诊断的枸橼酸化全血分析自动化。枸橼酸血中凝血因子的分析需要大量人力才能实现快速周转；因此，这一分析过程的自动化很有吸引力。因此，我们采用系统的自动化设计和工程方法创建了一个自动化凝血工作站。首先，我们使用离散事件模拟来计算潜在通量，并识别拟议的凝血工作单元可能存在的瓶颈。然后，我们创建了工作站的三维动画计算机模型，以简化工作站设计。最后，我们使用移动机器人、关节式机器人手臂和凝血分析系统构建了一个原型工作单元。
