Benbow S J, Wallymahmed M E, MacFarlane I A
Department of Medicine, University of Liverpool, UK.
QJM. 1998 Nov;91(11):733-7. doi: 10.1093/qjmed/91.11.733.
The quality of life (QOL) of 79 people with type 1 and type 2 diabetes and 37 non-diabetic controls was assessed using the Nottingham Health Profile (NHP). The NHP consists of six domains assessing energy, sleep, pain, physical mobility, emotional reactions and social isolation. Symptomatic diabetic neuropathy was present in 41 of the patients. The neuropathy patients had significantly higher scores (impaired QOL) in 5/6 NHP domains than either the other diabetic patients (p < 0.01) or the non-diabetic (p < 0.001) controls. These were: emotional reaction, energy, pain, physical mobility and sleep. The diabetic patients without neuropathy also had significantly impaired QOL for 4/6 NHP domains compared with the non-diabetic control group (p < 0.05) (energy, pain, physical mobility and sleep). This quantification of the detrimental effect on QOL of diabetes, and in particular of chronic symptomatic peripheral diabetic neuropathy, emphasizes the need for further research into effective management of these patients.
采用诺丁汉健康量表（NHP）对79例1型和2型糖尿病患者以及37例非糖尿病对照者的生活质量（QOL）进行了评估。NHP由六个领域组成，评估精力、睡眠、疼痛、身体活动能力、情绪反应和社交孤立感。41例患者存在有症状的糖尿病神经病变。与其他糖尿病患者（p<0.01）或非糖尿病（p<0.001）对照者相比，神经病变患者在NHP的5/6个领域中得分显著更高（生活质量受损）。这些领域包括：情绪反应、精力、疼痛、身体活动能力和睡眠。与非糖尿病对照组相比，无神经病变的糖尿病患者在NHP的4/6个领域中生活质量也显著受损（p<0.05）（精力、疼痛、身体活动能力和睡眠）。对糖尿病，尤其是慢性有症状的糖尿病周围神经病变对生活质量的有害影响进行的这种量化，强调了对这些患者的有效管理进行进一步研究的必要性。
