Tanabe T, Suzuki S, Shimakawa S, Yamashiro K, Tamai H
Division of Pediatrics, Hirakata City Hospital, Osaka.
No To Hattatsu. 1999 Jan;31(1):14-20.
Lidocaine was administered intravenously as a substitute for diazepam, to 12 patients with status epilepticus or clustering seizures aged 26 days to 11 years. The medication was very effective in 3 cases with acute convulsions, which disappeared immediately after infusion of lidocaine without relapse. The medication was effective only temporarily in 4 patients; they experienced relapsing seizures during drip infusion of lidocaine intravenously for maintenance. All the relapsing seizures were secondarily generalized ones with diffuse ictal discharges. In 2 cases of localization-related epilepsy, complex partial seizures evolved to secondarily generalized seizures immediately after administration of lidocaine. It must be noticed that in a relatively large number of cases lidocaine is ineffective or even harmful.
对12例年龄在26天至11岁之间的癫痫持续状态或成串发作的患者静脉注射利多卡因以替代地西泮。该药物对3例急性惊厥患者非常有效，静脉输注利多卡因后惊厥立即消失且未复发。该药物对4例患者仅暂时有效；他们在静脉滴注利多卡因维持治疗期间出现复发癫痫发作。所有复发癫痫发作均为继发全身性发作且伴有弥漫性发作期放电。在2例局灶性相关性癫痫患者中，利多卡因给药后复杂部分性发作立即演变为继发全身性发作。必须注意的是，在相当多的病例中，利多卡因无效甚至有害。
