Aziz W, Firrell J C, Ogden L, Breidenbach W C
Christine M. Kleinert Institute for Hand and Micro Surgery, Louisville, Kentucky 40202, USA.
J Reconstr Microsurg. 1999 Jan;15(1):47-53. doi: 10.1055/s-2007-1000070.
A model of chronic entrapment neuropathy in the rabbit sciatic nerve was developed to try to elucidate the pathogenesis of chronic nerve entrapment. A non-compressive Silastic cuff was wrapped around the nerve at the mid-thigh level in eight rabbits. A sham operation that only elevated the sciatic nerve was performed in seven control rabbits. Six months later, the blood flow in the cuffed and the control sciatic nerves was determined with intra-arterially injected microspheres. Blood flow was significantly reduced in the entrapped nerve, compared to control nerves, but only in the segment proximal to the cuff. After surgical release of the cuff, the blood flow significantly increased in the proximal segment. This suggested that decreased blood flow may occur, but not necessarily at the site of nerve entrapment. Nerve conduction velocity changes were also consistent with an entrapment neuropathy. However, there were no significant quantitative morphometric changes at the nerve entrapment site, that is, in myelin thickness/nerve diameter ratio, distribution of axon sizes, and mean nerve fiber diameter. This indicates that only a mild entrapment was created.
建立了兔坐骨神经慢性卡压性神经病模型，以试图阐明慢性神经卡压的发病机制。在8只兔子的大腿中部水平，用无压迫的硅橡胶袖带包裹神经。7只对照兔子进行仅抬高坐骨神经的假手术。6个月后，用动脉内注射微球的方法测定被袖带包裹的坐骨神经和对照坐骨神经的血流。与对照神经相比，被卡压神经的血流显著减少，但仅在袖带近端的节段。袖带手术松解后，近端节段的血流显著增加。这表明血流可能减少，但不一定发生在神经卡压部位。神经传导速度的变化也与卡压性神经病一致。然而，在神经卡压部位，即髓鞘厚度/神经直径比、轴突大小分布和平均神经纤维直径方面，没有显著的定量形态学变化。这表明仅造成了轻度卡压。
