胆碱能抑制人体肠道碳酸氢盐吸收的间接证据。
Indirect evidence for cholinergic inhibition of intestinal bicarbonate absorption in humans.
作者信息
Mellander A, Sjövall H
机构信息
Department of Internal Medicine, University of Göteborg, Sweden.
出版信息
Gut. 1999 Mar;44(3):353-60. doi: 10.1136/gut.44.3.353.
BACKGROUND
The aim of the study was to test the hypothesis that in the fasting state, proximal intestinal HCO3- absorption, which depends on villus Na+/H+ exchanger activity, is tonically inhibited by a cholinergic atropine sensitive mechanism.
SUBJECTS
The experiments were performed in 34 healthy volunteers and in eight patients with intestinal villus atrophy.
METHODS
HCO3- absorption was measured with a modified triple lumen perfusion technique in the distal duodenum, the most proximal portion of the small intestine. The study was designed to compensate for the inhibitory effects of atropine on intestinal motor activity.
RESULTS
Atropine had three effects on HCO3- transport: it reduced HCO3- concentration at the proximal aspiration site, it displaced the relation between HCO3- concentration and HCO3- absorption to the left, and it induced a significant acidification of the perfusate at the distal aspiration site. The magnitude of the stimulatory effect on HCO3- absorption was similar to the difference between patients with intestinal villus atrophy and healthy controls.
CONCLUSION
The data suggest that, in the fasting state, duodenal HCO3- absorption, which depends on villus Na+/H+ exchanger activity, may be tonically inhibited by an atropine sensitive cholinergic mechanism.
背景
本研究的目的是检验以下假设：在禁食状态下，依赖绒毛钠/氢交换体活性的近端肠道碳酸氢根吸收受到一种对阿托品敏感的胆碱能机制的紧张性抑制。
研究对象
实验在34名健康志愿者和8名肠道绒毛萎缩患者中进行。
方法
采用改良的三腔灌注技术在十二指肠远端（小肠最近端部分）测量碳酸氢根吸收。该研究旨在补偿阿托品对肠道运动活性的抑制作用。
结果
阿托品对碳酸氢根转运有三种作用：它降低了近端抽吸部位的碳酸氢根浓度，使碳酸氢根浓度与碳酸氢根吸收之间的关系向左移位，并且它在远端抽吸部位引起灌注液显著酸化。对碳酸氢根吸收的刺激作用程度与肠道绒毛萎缩患者和健康对照者之间的差异相似。
结论
数据表明，在禁食状态下，依赖绒毛钠/氢交换体活性的十二指肠碳酸氢根吸收可能受到对阿托品敏感的胆碱能机制的紧张性抑制。
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