Dehen L, Vilmer C, Humilière C, Corcos T, Pentousis D, Ollivaud L, Chatelain D, Dubertret L
Skin Research Institute and the Department of Pathology, Saint Louis University Hospital, Paris, France.
Heart. 1999 Mar;81(3):308-12. doi: 10.1136/hrt.81.3.308.
Cardiac angiography produces one of the highest radiation exposures of any commonly used diagnostic x ray procedure. Recently, serious radiation induced skin injuries have been reported after repeated therapeutic interventional procedures using prolonged fluoroscopic imaging. Two male patients, aged 62 and 71 years, in whom chronic radiodermatitis developed one to two years after two consecutive cardiac catheterisation procedures are reported. Both patients had undergone lengthy procedures using prolonged fluoroscopic guidance in a limited number of projections. The resulting skin lesions were preceded, in one case, by an acute erythema and took the form of a delayed pigmented telangiectatic, indurated, or ulcerated plaque in the upper back or below the axilla whose site corresponded to the location of the x ray tube during cardiac catheterisation. Cutaneous side effects of radiation exposure result from direct damage to the irradiated tissue and have known thresholds. The diagnosis of radiation induced skin injury relies essentially on clinical and histopathological findings, location of skin lesions, and careful medical history. Interventional cardiologists should be aware of this complication, because chronic radiodermatitis may result in painful and resistant ulceration and eventually in squamous cell carcinoma.
心脏血管造影术在所有常用的诊断性X射线检查中产生的辐射暴露量是最高的之一。最近,有报道称在使用长时间荧光透视成像进行反复治疗性介入手术后出现了严重的辐射诱发皮肤损伤。本文报告了两名男性患者,年龄分别为62岁和71岁,他们在连续两次心脏导管插入术后一到两年出现了慢性放射性皮炎。两名患者均在有限的投照角度下接受了长时间的荧光透视引导下的手术。在其中一例中,皮肤病变之前出现了急性红斑,表现为上背部或腋窝下方延迟出现的色素沉着性毛细血管扩张、硬结或溃疡斑块,其部位与心脏导管插入术期间X射线管的位置相对应。辐射暴露的皮肤副作用是由对受照射组织的直接损伤引起的,并且有已知的阈值。辐射诱发皮肤损伤的诊断主要依赖于临床和组织病理学检查结果、皮肤病变的位置以及详细的病史。介入心脏病学家应该意识到这种并发症,因为慢性放射性皮炎可能导致疼痛且难治的溃疡,最终发展为鳞状细胞癌。