钙离子在离体豚鼠输精管中诱导的收缩。

The contraction induced by calcium ions in isolated guinea-pig vas deferens.

Sugimoto J, Furumichi A, Murakami M

Clin Exp Pharmacol Physiol. 1978 Jul-Aug;5(4):379-82. doi: 10.1111/j.1440-1681.1978.tb00686.x.

Abstract

When isolated guinea-pig vas deferens was pretreated with 0.01% sodium edetate in an isotonic sucrose medium and then transferred to an edetate-free sucrose medium, the addition of CaCl2 (1.1 to 35.2 mmol/l) induced a contraction. 2. The contraction was greatest when the CaCl2 was added soon after pretreatment with edetate, and decreased with increasing time, almost disappearing after 1 h. 3. When KCl (1.4 to 22.4 mmol/l) was added in place of CaCl2, the contraction was lowest soon after pretreatment with edetate, and increased with time; after 1 h, the effect, was 80.7% of that observed in a preparation that had not been pretreaated with edetate.

摘要

将离体豚鼠输精管在等渗蔗糖培养基中用0.01%依地酸钠预处理，然后转移至不含依地酸的蔗糖培养基中，加入氯化钙（1.1至35.2 mmol/L）会引起收缩。2. 在依地酸预处理后不久加入氯化钙时收缩最大，且随时间增加而减小，1小时后几乎消失。3. 当加入氯化钾（1.4至22.4 mmol/L）代替氯化钙时，依地酸预处理后不久收缩最小，且随时间增加而增大；1小时后，其效应为未用依地酸预处理的标本中观察到的效应的80.7%。