Santamore W P, Lynch P R, Heckman J L, Bove A A, Meier G D
J Appl Physiol. 1976 Dec;41(6):925-30. doi: 10.1152/jappl.1976.41.6.925.
The possibility that left ventricular (LV) performance might affect right ventricular (RV) function through the myocardium was examined by using isolated, flow-perfused, paced rabbit hearts beating isovolumically. Reducing LV volume from its optimal volume to zero caused a 5.7% decrease (N = 10, P less than 0.001) in right ventricular developed pressure (RVDP). Ligating the anterior ventricular branches of the left coronary artery which in the rabbit supply the LV free wall resulted in an additional 9.3% decrease in RVDP (N = 5, P = 0.05) within 3 min of ligation. Finally, cutting the LV free wall from the atrioventricular orifice to the apex (thereby preventing any developed LV free wall force during systole) caused a 45% further decrease in RVDP (N = 2, P less than 0.02). Cineradiographic study showed that the alterations in RVDP resulting from changes in LV volume and coronary occlusion correlated significantly (N = 5, P less than 0.01) with the magnitude of septal bulging into the RV cavity during systole. The results indicate that alteration in LV free wall function and changes in LV volume can directly effect RVDP through the myocardium.
利用离体的、血流灌注的、等容起搏的兔心脏，研究左心室（LV）功能是否可能通过心肌影响右心室（RV）功能。将左心室容积从最佳容积降至零，右心室舒张末压（RVDP）下降5.7%（N = 10，P < 0.001）。结扎兔左冠状动脉供应左心室游离壁的前室支，结扎后3分钟内右心室舒张末压又额外下降9.3%（N = 5，P = 0.05）。最后，将左心室游离壁从房室口至心尖切断（从而在收缩期防止左心室游离壁产生任何作用力），右心室舒张末压进一步下降45%（N = 2，P < 0.02）。心血管造影研究显示，左心室容积变化和冠状动脉闭塞引起的右心室舒张末压改变与收缩期室间隔凸入右心室腔的程度显著相关（N = 5，P < 0.01）。结果表明，左心室游离壁功能改变和左心室容积变化可通过心肌直接影响右心室舒张末压。
