Saito H, Tsujitani S, Kondo A, Ikeguchi M, Maeta M, Kaibara N
First Department of Surgery, Tottori University School of Medicine, Yonago, Japan.
Surgery. 1999 Feb;125(2):195-201.
It has recently been reported that the microvessel density in a tumor correlates with hematogenous metastasis in gastric carcinoma. The aim of this study was to evaluate the relationship between the expression of vascular endothelial growth factor (VEGF), which was thought to be a potent angiogenesis-promoting factor, and hematogenous recurrence in advanced gastric carcinoma.
The expression of VEGF and the density of the microvessels were examined by immunohistochemistry in patients with advanced gastric carcinoma with serosal invasion who had undergone curative resection.
The prognosis of patients with a VEGF-negative tumor was significantly better than that of patients with a VEGF-positive tumor. Multivariate analysis by Cox proportional hazards model showed that the expression of VEGF was an independent prognostic indicator. The expression of VEGF provided a significant estimate of relative risk for the development of hematogenous recurrence by multivariate logistic regression analysis. The microvessel count in VEGF-positive tumors was significantly higher than that in VEGF-negative tumors.
VEGF is associated with hematogenous recurrence. Assessment of the expression of VEGF may therefore prove valuable in identifying patients with gastric carcinoma at high risk for recurrence who would benefit from adjuvant therapy.
最近有报道称，肿瘤中的微血管密度与胃癌的血行转移相关。本研究的目的是评估血管内皮生长因子（VEGF）的表达与进展期胃癌血行复发之间的关系，VEGF被认为是一种有效的促血管生成因子。
采用免疫组织化学法检测接受根治性切除的伴有浆膜侵犯的进展期胃癌患者的VEGF表达和微血管密度。
VEGF阴性肿瘤患者的预后明显好于VEGF阳性肿瘤患者。Cox比例风险模型多因素分析显示，VEGF表达是一个独立的预后指标。通过多因素logistic回归分析，VEGF表达对血行复发发生的相对风险有显著评估价值。VEGF阳性肿瘤中的微血管计数显著高于VEGF阴性肿瘤。
VEGF与血行复发相关。因此，评估VEGF表达可能有助于识别复发风险高且能从辅助治疗中获益的胃癌患者。
