Miyazaki S, Imaizumi M, Abiru T, Machida H
Biology Laboratory, Yamasa Corporation, Choshi, Chiba, Japan.
Life Sci. 1999;64(1):45-52. doi: 10.1016/s0024-3205(98)00532-3.
The effects of nucleotides on learning and memory were studied in normal and basal forebrain-lesioned rats using a Morris water maze test. Chronic oral administration of a nucleotide mixture (500 mg/kg), containing an equal weight of the disodium salts of adenosine 5'-monophosphate, guanosine 5'-monophosphate, inosine 5'-monophosphate, cytidine 5'-monophosphate, and uridine 5'-monophosphate facilitated learning acquisition in normal rats. In basal forebrain-lesioned rats, administration of the nucleotide mixture showed a tendency to improve learning acquisition and memory retrieval. In the biochemical studies, no significant changes were observed in brain choline and acetylcholine levels by treatment with the nucleotide mixture at the doses tested in both normal and basal forebrain-lesioned rats. The nucleotides did not affect the monoaminergic systems in normal rats, but did cause some changes in these systems in basal forebrain-lesioned rats. The present studies indicate that nucleotides ameliorate learning and memory processes in normal rats, but not in basal forebrain-lesioned rats, and they also modulate the activity of the central monoaminergic systems under certain conditions.
使用莫里斯水迷宫试验，研究了核苷酸对正常大鼠和基底前脑损伤大鼠学习与记忆的影响。长期口服一种核苷酸混合物（500毫克/千克），该混合物含有等量的5'-单磷酸腺苷二钠盐、5'-单磷酸鸟苷、5'-单磷酸肌苷、5'-单磷酸胞苷和5'-单磷酸尿苷，可促进正常大鼠的学习获得。在基底前脑损伤大鼠中，给予核苷酸混合物显示出改善学习获得和记忆提取的趋势。在生化研究中，在正常大鼠和基底前脑损伤大鼠中测试的剂量下，用核苷酸混合物处理后，脑胆碱和乙酰胆碱水平未观察到显著变化。核苷酸对正常大鼠的单胺能系统没有影响，但在基底前脑损伤大鼠中确实引起了这些系统的一些变化。目前的研究表明，核苷酸可改善正常大鼠的学习和记忆过程，但对基底前脑损伤大鼠无效，并且它们还在某些条件下调节中枢单胺能系统的活性。
