三种HIV-1 mRNA的Rev依赖性表达（综述）

Rev-dependent expression of three species of HIV-1 mRNAs (review).

作者信息

Fukumori T, Kagawa S, Iida S, Oshima Y, Akari H, Koyama A H, Adachi A

机构信息

Department of Urology, The University of Tokushima School of Medicine, Tokushima 770-8503, Japan.

出版信息

Int J Mol Med. 1999 Mar;3(3):297-302. doi: 10.3892/ijmm.3.3.297.

DOI:10.3892/ijmm.3.3.297

PMID:10028055

Abstract

The expression of structural and accessory genes of human immunodeficiency virus type 1 (HIV-1) except for nef requires a viral regulatory protein Rev. Rev-dependency of the expression of structural (gag, pol and env), regulatory (tat and rev), and accessory genes (vif, vpr, vpu and nef) has been investigated by various systems, and it has been demonstrated that unspliced (encodes gag and pol) and singly-spliced (env-vpu, vif and vpr) viral mRNAs are differentially dependent on the function of Rev. In this review, the function of HIV-1 Rev in relation to these findings is discussed.

摘要

除nef外，人类免疫缺陷病毒1型（HIV-1）的结构基因和辅助基因的表达需要一种病毒调节蛋白Rev。通过各种系统研究了结构基因（gag、pol和env）、调节基因（tat和rev）以及辅助基因（vif、vpr、vpu和nef）表达对Rev的依赖性，结果表明，未剪接的（编码gag和pol）和单剪接的（env-vpu、vif和vpr）病毒mRNA对Rev功能的依赖性存在差异。在这篇综述中，将讨论HIV-1 Rev与这些发现相关的功能。