Korsak Z, Majcherek W, Rydzyński K
Department of Toxicity and Carcinogenesis, Nofer Institute of Occupational Medicine, Lódź, Poland.
Int J Occup Med Environ Health. 1998;11(4):335-42.
Neurotoxic and sensory respiratory irritation effects of 1-methylnaphthalene and 2-methylnaphthalene in male rats and male Balb/C mice were investigated under conditions of acute inhalation exposure. Rotarod performance and pain sensitivity behaviour were tested in rats exposed to 1-methylnaphthalene at concentrations of 152-407 mg/m3, and 2-methylnaphthalene at concentrations of 229-522 mg/m3 immediately after termination of a four-hour exposure. The respiratory rate was measured in mice by the whole body pletysmographic method in 6 min duration exposure to various concentrations of 1-methylnaphthalene and 2-methylnaphthalene. Exposure to both methylated naphthalene derivatives resulted in concentration-dependent decrease in pain sensitivity in rats and depression of respiratory rate and mice. At the concentrations applied no statistically significant disturbances in rotarod performance behaviour were observed. The concentrations depressing the respiratory rate to 50% (RD50) were 129 mg/m3 and 67 mg/m3, for 1-methylnaphthalene and 2-methylnaphthalene, respectively. As based on RD50 values, the MAC values of 4 mg/m3 for 1-methylnaphthalene, and of 2 mg/m3 for 2-methylnaphthalene are suggested.
在急性吸入暴露条件下，研究了1-甲基萘和2-甲基萘对雄性大鼠和雄性Balb/C小鼠的神经毒性和感觉性呼吸道刺激作用。在暴露4小时结束后，立即对暴露于浓度为152 - 407 mg/m³的1-甲基萘和浓度为229 - 522 mg/m³的2-甲基萘的大鼠进行转棒试验和疼痛敏感性行为测试。通过全身体积描记法在暴露于各种浓度的1-甲基萘和2-甲基萘6分钟期间测量小鼠的呼吸频率。暴露于两种甲基化萘衍生物均导致大鼠疼痛敏感性呈浓度依赖性降低，以及小鼠呼吸频率降低。在所应用的浓度下，未观察到转棒性能行为有统计学上的显著干扰。使呼吸频率降低50%（RD50）的浓度，1-甲基萘为129 mg/m³，2-甲基萘为67 mg/m³。基于RD50值，建议1-甲基萘的MAC值为4 mg/m³，2-甲基萘的MAC值为2 mg/m³。
