Borrelli B, Spring B, Niaura R, Kristeller J, Ockene J K, Keuthen N J
Center for Behavioral and Preventive Medicine, Brown University School of Medicine, Providence, Rhode Island 02906, USA.
J Consult Clin Psychol. 1999 Feb;67(1):124-31. doi: 10.1037//0022-006x.67.1.124.
Fluoxetine's effect (30 mg, 60 mg, and placebo) on postcessation weight gain was studied among participants from a randomized, double-blind 10-week smoking cessation trial who met strict criteria for abstinence and drug levels. It was hypothesized that (a) fluoxetine would dose-dependently suppress postcessation weight gain and (b) drug discontinuation would produce dose-dependent weight rebound. During the on-drug phase, placebo participants gained weight linearly (M = 2.61 kg). exceeding both fluoxetine groups (30-mg group M = 1.33 kg, 60-mg group M = 1.25 kg). Weight suppression was initially greater for 60 mg than 30 mg, but both were followed by weight gain. Six months off drug produced greater dose-dependent weight rebound for 60 mg than 30 mg or placebo. Considering both on- and off-drug phases, weight gain for 60 mg of fluoxetine (M = 6.5 kg) was comparable with that for placebo (M = 4.7 kg) but greater than that for 30 mg (M = 3.6 kg). Fluoxetine appears to forestall postcessation weight gain, allowing time for the weight-conscious smoker to focus on quitting smoking rather than on preventing weight gain.
在一项为期10周的随机双盲戒烟试验中，对符合严格戒烟和药物水平标准的参与者研究了氟西汀（30毫克、60毫克和安慰剂）对戒烟后体重增加的影响。研究假设为：（a）氟西汀将呈剂量依赖性抑制戒烟后体重增加；（b）停药将产生剂量依赖性体重反弹。在服药阶段，安慰剂组参与者体重呈线性增加（M = 2.61千克），超过了两个氟西汀组（30毫克组M = 1.33千克，60毫克组M = 1.25千克）。最初，60毫克组的体重抑制作用大于30毫克组，但随后两组均出现体重增加。停药6个月后，60毫克组比30毫克组或安慰剂组产生更大的剂量依赖性体重反弹。综合服药和停药阶段来看，60毫克氟西汀组的体重增加量（M = 6.5千克）与安慰剂组（M = 4.7千克）相当，但大于30毫克组（M = 3.6千克）。氟西汀似乎可以延缓戒烟后体重增加，让关注体重的吸烟者有时间专注于戒烟而非预防体重增加。
