Shimada K, Kondo T, Matsumura Y, Okada Y, Fujimura S
Department of Thoracic Surgery, Tohoku University, Sendai, Japan.
Nihon Geka Gakkai Zasshi. 1998 Nov;99(11):759-64.
Lung transplantation has been established as an optional treatment for irreversible diffuse lung disease. To date, more than 8,000 patients have undergone lung transplantation, while heart-lung transplantation is confined to a very limited number of cases due to the severe shortage of donors. There are various problems in clinical lung transplantation, including limited preservation time, post-transplantation edema, acute and chronic rejection, and a shortage of donor organs. Several solutions to these problems have been found in recent experimental studies. For example, potential therapies for posttransplantation edema have been proposed, and the possibility of long-term preservation has been suggested. Research on xenotransplantation and cadaveric lung transplantation is ongoing, and this may result in options to solve the problem of the shortage of donor organs. In particular, we believe that cadaveric lung transplantation has the potential to become a clinically useful therapy in the near future.
肺移植已被确立为不可逆弥漫性肺部疾病的一种可选治疗方法。迄今为止，已有8000多名患者接受了肺移植，而由于供体严重短缺，心肺移植仅限于极少数病例。临床肺移植存在各种问题，包括保存时间有限、移植后水肿、急慢性排斥反应以及供体器官短缺。最近的实验研究已经找到了这些问题的几种解决方案。例如，已经提出了针对移植后水肿的潜在治疗方法，并提出了长期保存的可能性。异种移植和尸体肺移植的研究正在进行中，这可能会带来解决供体器官短缺问题的选择。特别是，我们相信尸体肺移植在不久的将来有可能成为一种临床上有用的治疗方法。
