Umeshita K, Monden M
Surgical Center, Osaka University Medical School, Osaka, Japan.
Nihon Geka Gakkai Zasshi. 1998 Nov;99(11):776-80.
Organ preservation is currently performed by simple cold storage or continuous hypothermic perfusion. Cold storage using University of Wisconsin (UW) solution greatly prolongs the successful preservation period for abdominal organs such as the kidney, liver, and pancreas. Thoracic organs (heart, lung), however, can be preserved for only several hours even with UW solution. As a result of improvements in organ transplantation, the number of patients on waiting lists has grown rapidly. Unfortunately, many patients die while waiting for donor organs, and expansion of the donor pool is mandatory. Possible solutions to the shortage of donor organs include the use of marginal donors and non-heart-beating donors. For this purpose, more sophisticated methods of organ preservation are needed, and therefore extensive investigations using current technologies including gene transfer should be performed. Every effort should be made to accommodate the preferences of donors.
目前，器官保存通过简单的冷藏或持续低温灌注来进行。使用威斯康星大学（UW）溶液进行冷藏可大大延长肾脏、肝脏和胰腺等腹部器官的成功保存时间。然而，即使使用UW溶液，胸部器官（心脏、肺）也只能保存几个小时。由于器官移植技术的改进，等待移植的患者数量迅速增加。不幸的是，许多患者在等待供体器官时死亡，因此扩大供体库势在必行。解决供体器官短缺的可能办法包括使用边缘供体和非心脏跳动供体。为此，需要更先进的器官保存方法，因此应利用包括基因转移在内的现有技术进行广泛研究。应尽一切努力满足供体的意愿。
