Yüksel A, Cengiz M, Seven M, Cengiz S, Cenani A
Division of Neurogenetics and Biochemistry, Istanbul University, Cerrahpaşa Medical Faculty, Genetic and Teratology Research Center (Getam), Turkey.
Pediatr Neurol. 1999 Jan;20(1):24-6. doi: 10.1016/s0887-8994(98)00079-4.
To evaluate renal tubular function in children receiving antiepileptic drugs the urinary activity of two lysosomal enzymes, N-acetyl-beta-glucosaminidase and beta-galactosidase, were measured. The enzyme levels were determined before the administration of antiepileptic drugs and 8 months after. Fourteen epileptic children received valproate, and 17 received carbamazepine. The urinary activity of these enzymes in 25 healthy control patients also was examined. Increased N-acetyl-beta-glucosaminidase activity was found in 50% of patients taking valproate and in 17.6% of patients taking carbamazepine. Increased beta-galactosidase activity was found in 28.5% of patients taking valproate and 11.7% of patients taking carbamazepine compared with the results before treatment. On the basis of these results, it is suggested that patients taking antiepileptic drugs, especially valproate, may demonstrate minor signs of tubular dysfunction. In those patients who use these drugs at increased dosage levels or for long periods, the possibility of tubular dysfunction may be increased, and these dysfunctions may manifest in clinical symptoms.
为评估接受抗癫痫药物治疗的儿童的肾小管功能，检测了两种溶酶体酶——N - 乙酰 - β - 氨基葡萄糖苷酶和β - 半乳糖苷酶的尿活性。在给予抗癫痫药物之前及之后8个月测定酶水平。14名癫痫儿童接受丙戊酸盐治疗，17名接受卡马西平治疗。还检测了25名健康对照患者的这些酶的尿活性。服用丙戊酸盐的患者中有50%以及服用卡马西平的患者中有17.6%发现N - 乙酰 - β - 氨基葡萄糖苷酶活性增加。与治疗前结果相比，服用丙戊酸盐的患者中有28.5%以及服用卡马西平的患者中有11.7%发现β - 半乳糖苷酶活性增加。基于这些结果，提示服用抗癫痫药物的患者，尤其是丙戊酸盐，可能表现出肾小管功能障碍的轻微迹象。在那些增加药物剂量或长期使用这些药物的患者中，肾小管功能障碍的可能性可能增加，并且这些功能障碍可能表现为临床症状。
