Dobbins J G, Mastro T D, Nopkesorn T, Sangkharomya S, Limpakarnjanarat K, Weniger B G, Schmid D S
Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Sex Transm Dis. 1999 Feb;26(2):67-74. doi: 10.1097/00007435-199902000-00001.
To compare the epidemiologic pattern of HIV-1, a recently introduced sexually transmitted disease (STD) agent in Thailand, with the pattern of HSV-2, a well-established STD agent, so that future trends for both viruses can be better understood.
We obtained questionnaire data and determined HSV-2 (by specific gG-2) and HIV-1 seroreactivity in a cohort of 1,115 young male army conscripts who entered service in northern Thailand in 1991.
Seroprevalence of HIV-1 and HSV-2 was 6.9% and 14.9%, respectively. For HSV-2-seropositive men who reported previous genital ulcers, HIV-1 seroprevalence was 32%. For most variables, there was a close correspondence between the prevalence ratios for HIV-1 and for HSV-2, except that prevalence ratios for HIV-1 tended to be greater than the corresponding ratios for HSV-2. The seroprevalence of both viruses was strongly related to early and frequent contact with female sex workers (FSWs), infrequent use of condoms with FSWs, and residence in the upper north region of Thailand. When differences in sexual behavior between the upper north and lower north were controlled for, the seroprevalence of both viruses still differed significantly by region.
Although the seroprevalence levels of HSV-2 and HIV-1 were quite different in this cohort of Thai army conscripts in 1991, the patterns of infection in terms of demographic, residential, and behavioral variables were similar. Seroprevalence studies of HSV-2 in other populations, particularly where the HIV-1 epidemic is just beginning, may be useful in predicting which subgroups might be most vulnerable to the epidemic and could therefore benefit the most from public health intervention. Where differences in the patterns of the two viruses have been noted, we hypothesize that the pattern for HIV-1 will evolve toward that seen for HSV-2.
比较人类免疫缺陷病毒1型（HIV-1，一种最近在泰国出现的性传播疾病病原体）和单纯疱疹病毒2型（HSV-2，一种已被充分认知的性传播疾病病原体）的流行病学模式，以便更好地了解这两种病毒未来的发展趋势。
我们获取了问卷调查数据，并对1991年在泰国北部入伍的1115名年轻男性新兵进行队列研究，通过特异性gG-2检测HSV-2和HIV-1血清反应性。
HIV-1和HSV-2的血清阳性率分别为6.9%和14.9%。在报告有既往生殖器溃疡的HSV-2血清阳性男性中，HIV-1血清阳性率为32%。对于大多数变量，HIV-1和HSV-2的患病率比值之间存在密切对应关系，但HIV-1的患病率比值往往高于HSV-2的相应比值。两种病毒的血清阳性率都与早期频繁接触女性性工作者、与女性性工作者性交时不经常使用避孕套以及居住在泰国北部上区密切相关。在控制了泰国北部上区和下区性行为差异后，两种病毒的血清阳性率在不同地区仍存在显著差异。
尽管在1991年这群泰国新兵中HSV-2和HIV-1的血清阳性率水平差异很大，但在人口统计学、居住和行为变量方面的感染模式相似。对其他人群，特别是HIV-1疫情刚刚开始的地区进行HSV-2血清阳性率研究，可能有助于预测哪些亚组最易感染该流行病，从而可能从公共卫生干预中获益最大。在注意到两种病毒模式存在差异的地方，我们推测HIV-1的模式将朝着HSV-2的模式发展。
