Goëau-Brissonnière O, Leflon V, Letort M, Nicolas M H
Division of Vascular Surgery, Ambroise Paré University Hospital, Boulogne, France.
Biomaterials. 1999 Feb;20(3):229-32. doi: 10.1016/s0142-9612(98)00164-1.
This study examines the efficacy of the bonding of rifampicin, vancomycin or gentamicin to gelatin-coated knitted polymer meshes to prevent perioperative infection. Antibiotic bonding was obtained by soaking the meshes for 15 min in a solution containing 20 mg ml(-1) of rifampicin or 10 mg ml(-1) of vancomycin or gentamicin. A polymer mesh was implanted in a subcutaneous pouch in 16 rabbits: four received a rifampicin-soaked mesh, four received a vancomycin-soaked mesh, four received a gentamicin-soaked mesh, and four received an untreated mesh (control group). At the time of implantation, all the meshes were contaminated locally with 10(8) colony forming units of Staphylococcus aureus. Meshes were harvested one week later and submitted to bacterial counts. At the time of explantation, none of the antibiotic-soaked meshes were infected, whereas all the untreated meshes were infected. These results show that antibiotic soaking evidently prevents perioperative infection of gelatin-coated knitted polymer meshes in this model.
本研究考察了利福平、万古霉素或庆大霉素与明胶涂层针织聚合物网片结合以预防围手术期感染的效果。通过将网片在含有20mg/ml利福平或10mg/ml万古霉素或庆大霉素的溶液中浸泡15分钟来实现抗生素结合。将聚合物网片植入16只兔子的皮下袋中：4只接受利福平浸泡的网片，4只接受万古霉素浸泡的网片，4只接受庆大霉素浸泡的网片，4只接受未处理的网片（对照组）。在植入时，所有网片均局部沾染10⁸个金黄色葡萄球菌菌落形成单位。一周后取出网片并进行细菌计数。在取出时，没有一个抗生素浸泡的网片被感染，而所有未处理的网片均被感染。这些结果表明，在该模型中，抗生素浸泡明显可预防明胶涂层针织聚合物网片的围手术期感染。
