Yang H Z, Lan J, Meng Y J, Wan X J, Han D W
Family Planning Research Institute of Sichuan, WHO Collaborating Centre for Research in Human Reproduction, Chengdu, People's Republic of China.
J Steroid Biochem Mol Biol. 1998 Dec;67(5-6):447-50. doi: 10.1016/s0960-0760(98)00120-4.
Nowadays research and clinical studies of human reproductive endocrinology are generally carried out using human blood reproductive hormone assays. However the acquisition of human blood samples has some shortcomings. In search of new approaches, we paid attention to the fact that progesterone can be detected in cow's hair. Consequently we investigated whether or not steroid hormones are measurable in human hair. The results showed that the levels of steroid hormones in hair are not affected by shampoo and do not significantly vary between different segments of hair (i.e. top, middle and basal segments). The menstrual estradiol and progesterone rhythm of female hair is similar to that of female serum. The ratio of hair estradiol to serum estradiol in the female is 41.2% and that of hair progesterone to serum progesterone is 59.0%; the ratio of hair testosterone to serum testosterone in male is 116%. There are significant correlations between hair and serum steroid hormones of healthy human adult: gamma (estradiol) = 0.395 (n = 20), p < 0.05; gamma (progesterone) = 0.440 (n = 22), p < 0.025 and gamma (testosterone) = 0.395 (n = 25), p < 0.05.
如今，人类生殖内分泌学的研究和临床研究通常使用人体血液生殖激素检测方法。然而，采集人体血液样本存在一些缺点。为了寻找新方法，我们注意到可以在牛毛中检测到孕酮。因此，我们研究了人类毛发中是否可检测到甾体激素。结果表明，毛发中甾体激素的水平不受洗发水影响，且在毛发的不同部位（即顶部、中部和基部）之间没有显著差异。女性毛发中的月经雌二醇和孕酮节律与女性血清中的相似。女性毛发雌二醇与血清雌二醇的比率为41.2%，毛发孕酮与血清孕酮的比率为59.0%；男性毛发睾酮与血清睾酮的比率为116%。健康成年人体内毛发和血清甾体激素之间存在显著相关性：γ（雌二醇）=0.395（n = 20），p < 0.05；γ（孕酮）=0.440（n = 22），p < 0.025；γ（睾酮）=0.395（n = 25），p < 0.05。
