Almeida R N, Navarro D S, de Assis T S, de Medeiros I A, Thomas G
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, Brazil.
J Ethnopharmacol. 1998 Dec;63(3):247-52. doi: 10.1016/s0378-8741(98)00086-5.
An ethanolic extract of the leaves of Cissampelos sympodialis Eichl. (Menispermaceae) was found to potentiate the toxicity of pentylenetetrazol in mice. Similar to imipramine, the extract also reduced the immobility period in the forced swimming test in mice and reversed the degree of ptosis and catalepsy induced by reserpine in rats. These results suggest that the extract possesses antidepressant activity and the reported phosphodiesterase inhibitory activity of the plant may account for the observed antidepressant effect.
发现锡生藤（防己科）叶的乙醇提取物可增强戊四氮对小鼠的毒性。与丙咪嗪类似，该提取物还缩短了小鼠强迫游泳试验中的不动时间，并逆转了利血平诱导的大鼠眼睑下垂和僵住程度。这些结果表明该提取物具有抗抑郁活性，且该植物报道的磷酸二酯酶抑制活性可能是观察到的抗抑郁作用的原因。
