Murray M
The University of Glasgow Veterinary School, Bearsdon, UK.
Vet Parasitol. 1999 Feb 25;81(2):149-58. doi: 10.1016/s0304-4017(98)00242-8.
I am extremely proud to receive the WAAVP/Pfizer Animal Health award, and particularly so in Africa, the continent where I have spent a large part of my professional life. In the nearly 40 years in research I have had the privilege and excitement of being involved with many great parasites, predators, places and people. In my early days in Kenya I saw all the great wild animal predators, but soon came to appreciate that the greatest predator of all was disease, particularly parasitic disease, with the devastating effects of tsetse and ticks and the infections they transmitted, and of the all-prevailing roundworms. I learned several key lessons while working with research teams to develop better diagnostics, to improve epidemiological understanding as a basis for rational treatment and control, and to extend the understanding of disease processes with the view to developing novel methods of treatment or prevention. The Power of Pathology in diagnosing diseases, identifying new diseases and as a major tool for pathogenic diseases. The Power of Pathogenesis in identifying key mechanisms that led to new diagnostic techniques, improved methods of treatment, and possibly to future vaccines. The Power of Application of what we already know; while recognising that molecular biology will make a massive contribution to improving animal and human health, it is important to appreciate that we already have a very powerful armamentaria to diagnose, treat, control or prevent disease, and when used properly they have been successful and cost-effective. The Power of Genetic Resistance: the recognition that certain species, certain breeds, and certain individuals within breeds possess remarkable resistance to certain parasitic diseases such as trypanosomosis and helminthosis, and that this trait is genetically correlated with production, opens up a very powerful additional approach to improving animal health. The Importance of Measurement: I completely endorse the sentiments of Lord Kelvin, Professor of Natural Philosophy at Glasgow University who stated in 1846: "When you can measure what you are speaking about, and express it in numbers, you know something about it: but when you cannot measure it, your knowledge is of a meagre and unsatisfactory kind." This applies very much to Parasitology. The future is bright. The combination and integration of the new technologies of Biotechnology, Mathematical Methods and Bioinformatics coupled with advances in Computer Power will produce new standards in animal and human health in the 21st century. New methods of predicting, diagnosis, treating, controlling, prognosing and preventing disease will become available. WAAVP has a major role to play by ensuring that veterinary parasitologists are provided with the proper training, infrastructure and forum to advance new technologies and that the veterinary profession plays a leading role in the future direction they take.
我非常荣幸能获得世界动物寄生虫学协会/辉瑞动物保健奖,尤其是在非洲获得该奖项,在这片大陆上我度过了职业生涯的大部分时光。在近40年的研究生涯中,我有幸参与了许多与伟大的寄生虫、捕食者、地方和人们相关的工作,并从中收获了诸多激动人心的经历。早年在肯尼亚时,我见到了所有伟大的野生动物捕食者,但很快我就意识到,最大的捕食者是疾病,尤其是寄生虫病,诸如采采蝇和蜱虫及其传播的感染所带来的毁灭性影响,以及无处不在的蛔虫感染。在与研究团队合作开发更好的诊断方法、增进对流行病学的理解以作为合理治疗和控制的基础,以及扩展对疾病过程的认识以开发新的治疗或预防方法的过程中,我学到了几个关键经验。病理学在诊断疾病、识别新疾病以及作为致病疾病的主要工具方面的力量。发病机制在识别导致新诊断技术、改进治疗方法以及可能开发未来疫苗的关键机制方面的力量。应用我们已知知识的力量;虽然认识到分子生物学将对改善动物和人类健康做出巨大贡献,但重要的是要认识到我们已经拥有非常强大的手段来诊断、治疗、控制或预防疾病,并且如果使用得当,它们是成功且具有成本效益的。遗传抗性的力量:认识到某些物种、某些品种以及品种内的某些个体对某些寄生虫病如锥虫病和蠕虫病具有显著抗性,并且这种特性与生产在遗传上相关,这为改善动物健康开辟了一种非常强大的额外途径。测量的重要性:我完全赞同格拉斯哥大学自然哲学教授开尔文勋爵在1846年所说的话:“当你能够测量你所谈论的事物,并能用数字表达它时,你对它就有所了解了:但当你无法测量它时,你的知识就是贫乏且不令人满意的。”这在寄生虫学中非常适用。未来是光明的。生物技术、数学方法和生物信息学等新技术与计算机能力的进步相结合,将在21世纪为动物和人类健康带来新的标准。预测、诊断、治疗、控制、预后和预防疾病的新方法将会出现。世界动物寄生虫学协会通过确保为兽医寄生虫学家提供适当的培训、基础设施和论坛以推动新技术发展,以及确保兽医行业在其未来发展方向中发挥主导作用,将发挥重要作用。