Puzantian T, Kawase K
Department of Psychiatry, San Francisco General Hospital, California 94110, USA.
Pharmacotherapy. 1999 Feb;19(2):205-12. doi: 10.1592/phco.19.3.205.30921.
Although in the last few years new antidepressants have become available in the United States, responses in many patients differ, from none, to partial, to delayed therapeutic response to the agents. If the antidepressant properties of these drugs could be enhanced or accelerated, it might be possible to improve patient functioning and quality of life. Pindolol, a serotonin 1A autoreceptor antagonist, accelerates and augments the therapeutic effects of antidepressants, especially selective serotonin reuptake inhibitors.
尽管在过去几年里美国已有新型抗抑郁药可供使用，但许多患者的反应各不相同，从无反应到部分反应，再到对这些药物的延迟治疗反应。如果这些药物的抗抑郁特性能够得到增强或加速，或许就有可能改善患者的功能和生活质量。吲哚洛尔是一种5-羟色胺1A自身受体拮抗剂，它能加速并增强抗抑郁药的治疗效果，尤其是选择性5-羟色胺再摄取抑制剂。
