Morales-Diaz M, Pinilla-Roa E, Ruiz I
Infectious Disease Service, Hospital Luis Calvo Mackenna, Santiago, Chile.
Pharmacotherapy. 1999 Feb;19(2):252-5. doi: 10.1592/phco.19.3.252.30918.
Carbamazepine is a potent anticonvulsant agent with proven efficacy in the treatment of partial and tonic-clonic seizures. An epileptic child treated with therapeutic dosages of carbamazepine developed severe hepatitis and hepatic insufficiency. She had a positive response to withdrawal of the drug and administration of corticosteroids. The Roussel UCLAF method for estimating causality of the adverse event was applied for an acute hepatocellular problem, with a final score of 8. This method has advantages over other tools because it involves many clinical factors that give additional guides to clinicians in patients with liver injury, but it must be adapted for adverse events in the pediatric population.
卡马西平是一种有效的抗惊厥药物，在治疗部分性发作和强直阵挛性发作方面已被证实有效。一名接受卡马西平治疗剂量的癫痫儿童出现了严重肝炎和肝功能不全。她对停药和使用皮质类固醇有积极反应。采用鲁塞尔·优克福（Roussel UCLAF）评估不良事件因果关系的方法来处理急性肝细胞问题，最终得分为8分。该方法比其他工具更具优势，因为它涉及许多临床因素，能为肝损伤患者的临床医生提供更多指导，但必须针对儿科人群的不良事件进行调整。
