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Analgesic-induced renal papillary necrosis in the Gunn rat: the comparative nephrotoxicity of aspirin and phenacetin.

作者信息

Axelsen R A

出版信息

J Pathol. 1976 Nov;120(3):145-50. doi: 10.1002/path.1711200303.

DOI:10.1002/path.1711200303
PMID:1003266
Abstract

Homozygous Gunn rats, mutant Wistars genetically lacking glucuronyl transferase, develop renal papillary necrosis after single oral doses of aspirin and of phenacetin. The lesion appears significantly more frequently with aspirin than phenacetin, and at lower doses. The model is a convenient one with which to study analgesic nephrotoxicity.

摘要

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引用本文的文献

1
Analgesic nephropathy: a reassessment of the role of phenacetin and other analgesics.镇痛剂肾病：对非那西丁及其他镇痛剂作用的重新评估
Drugs. 1982 Jan-Feb;23(1-2):75-149. doi: 10.2165/00003495-198223010-00004.
2
Nephrotoxicity of mild analgesics in the Gunn strain of rat.轻度镇痛药对冈恩品系大鼠的肾毒性
Br J Clin Pharmacol. 1980 Oct;10 Suppl 2(Suppl 2):309S-312S. doi: 10.1111/j.1365-2125.1980.tb01814.x.
3
Analgesic-associated nephropathy.镇痛药相关性肾病
Klin Wochenschr. 1987 Jan 5;65(1):1-16. doi: 10.1007/BF01785520.
4
Experimental renal papillary necrosis in the rat: the selective vulnerability of medullary structures to injury.
Virchows Arch A Pathol Anat Histol. 1978 Dec 12;381(1):79-84. doi: 10.1007/BF00433487.