Aoyama N, Shirasaka D, Sakai T, Shirakawa K
Department of Endoscopy, Kobe University School of Medicine.
Nihon Rinsho. 1999 Jan;57(1):43-52.
Eradication of Helicobacter pylori (H. pylori) is now established as main treatment of upper-gastrointestinal diseases. Resistance to H. pylori and acid condition in the stomach were important factors which influenced H. pylori eradication. Recolonized H. pylori strains will be easily resistant to metronidazole and clarithromycin, whereas almost all of H. pylori strains are sensitive to amoxicillin. On the other hand, amoxicillin targets cell wall biosynthesis and clarithromycin inhibits protein synthesis of Helicobacter pylori mainly in the growth phase which induced high intragastric pH condition, however, metronidazole targets DNA and, therefore, is independent of the stationary or growth phase distribution. To established a optimal regimen for Helicobacter pylori treatment, several factors included them should be account according to the parmacokinetical standings.
根除幽门螺杆菌（H. pylori）现已成为上消化道疾病的主要治疗方法。幽门螺杆菌耐药性和胃内酸性环境是影响幽门螺杆菌根除的重要因素。重新定植的幽门螺杆菌菌株很容易对甲硝唑和克拉霉素产生耐药性，而几乎所有幽门螺杆菌菌株对阿莫西林敏感。另一方面，阿莫西林靶向细胞壁生物合成，克拉霉素主要在胃内pH值升高的生长阶段抑制幽门螺杆菌的蛋白质合成，然而，甲硝唑靶向DNA，因此与静止期或生长期分布无关。为了制定最佳的幽门螺杆菌治疗方案，应根据药物动力学情况考虑其中包括的几个因素。
