Begić-Janev A, Lastić-Maletić S, Janev A, Radojković Z
Jugosl Ginekol Opstet. 1976 May-Jun;16(3):243-50.
A morphological study of two cases of acute generalized congenital toxoplasmosis has shown that in one case the most heavily involved organ was the heart (focal necrotic myocarditis), in addition to some changes in the central nervous system (leptomeningitis), and in the other case, the most affected organ was the cerebrum (focal necrotic encephalitis). In both cases, in almost all organs, there were degenerative and reactive changes. Toxoplasma was found in necrotic foci of the myocardium and the brain. Some basic views concerning a special vulnerability of the central nervous system in toxoplasmosis are put forward. The basic fact is that the explanation for the infection of exposed fetuses lies in the condition of the immune system (in the degree of its development and activity), especially regarding certain localizations of changes in the organs with a less developed activity of the local immune system.
对两例急性全身性先天性弓形虫病的形态学研究表明，在一例中，受累最严重的器官是心脏（局灶性坏死性心肌炎），此外中枢神经系统也有一些变化（软脑膜炎）；在另一例中，受影响最严重的器官是大脑（局灶性坏死性脑炎）。在这两例中，几乎所有器官都有退行性和反应性变化。在心肌和脑的坏死灶中发现了弓形虫。提出了关于弓形虫病中枢神经系统特殊易损性的一些基本观点。基本事实是，暴露胎儿感染的原因在于免疫系统的状况（其发育程度和活性），特别是关于局部免疫系统活性较低的器官中变化的某些定位。
