[Production of protease during continuous cultivation of the thermophilic bacterium Bacillus brevis].

Conditions for continuous cultivation of the thermophilic strain of Bacillus brevis prodlcing protease are substantiated. The culture was cultivated in order to obtain proteolytic enzymes taking into consideration data concerning kinetics of the bacterial growth and enzyme synthesis, as well as results of studying accumulation of the pool of mRNA specific of protease synthesis, The rates of dilution and flow (approximately 0.4 hr-1) have been found which provide a high specific productivity of the culture.