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烟酸耗竭糖原后大鼠肝脏中的丙酮酸激酶活性与糖异生作用

Pyruvate kinase activity and gluconeogenesis in rat liver after glycogen depletion with nicotinic acid.

作者信息

Moreno F J, Benito M, Sánchez-Medina F, Medina J M, Mayor F

出版信息

Mol Cell Biochem. 1976 Nov 30;13(2):89-93. doi: 10.1007/BF01837058.

DOI:10.1007/BF01837058
PMID:1004500
Abstract

Nicotinic acid administration, which depletes liver glycogen, leads to an increase of both pyruvate kinase L and phosphoenolypyruvate carboxykinase in liver by a factor of nearly two. The former is not prevented by either cycloheximide or actinomycin D. L-Cysteine, an allosteric inhibitor of pyruvate kinase L, favors gluconeogenesis from lactate in both nicotinic acid treated and starved animals.

摘要

给予烟酸会消耗肝糖原，导致肝脏中丙酮酸激酶L和磷酸烯醇丙酮酸羧激酶的含量均增加近两倍。前者不受放线菌酮或放线菌素D的抑制。L-半胱氨酸是丙酮酸激酶L的变构抑制剂，在烟酸处理的动物和饥饿的动物中均有利于乳酸生成葡萄糖。

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本文引用的文献

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THE ROLE OF PYRUVATE KINASE IN THE REGULATION OF GLUCONEOGENESIS.丙酮酸激酶在糖异生调节中的作用。
Biochem J. 1965 Jan;94:3C-4C. doi: 10.1042/bj0940003c.
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Renal gluconeogenesis. The effect of diet on the gluconeogenic capacity of rat-kidney-cortex slices.肾糖异生。饮食对大鼠肾皮质切片糖异生能力的影响。
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Effect of muscular exercise and glycogen depletion on rat liver and kidney phosphoenolpyruvate carboxykinase.肌肉运动和糖原耗竭对大鼠肝脏和肾脏磷酸烯醇丙酮酸羧激酶的影响。
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Gluconeogenesis in the perfused rat liver.灌注大鼠肝脏中的糖异生作用。
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Acute effects of nicotinic acid in the rat I. Plasma and liver lipids and blood glucose.烟酸对大鼠的急性作用 I. 血浆和肝脏脂质及血糖
Acta Med Scand. 1966 Apr;179(4):453-61. doi: 10.1111/j.0954-6820.1966.tb05483.x.
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Carbohydrate metabolism of the perfused rat liver.灌注大鼠肝脏的碳水化合物代谢
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Regulation of the pyruvate kinase of an established rat liver cell line (RLC) in culture by insulin, glucose and serum.
Biochem Biophys Res Commun. 1971 Jun 18;43(6):1211-8. doi: 10.1016/s0006-291x(71)80001-3.
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Evidence for a functional role of pyruvate kinase in decreasing gluconeogenesis in the perfused rat liver.丙酮酸激酶在降低灌注大鼠肝脏糖异生中的功能作用的证据。
Proc Soc Exp Biol Med. 1972 Sep;140(4):1399-401. doi: 10.3181/00379727-140-36682.
10
Regulation of rat liver pyruvate kinase. The effect of preincubation, pH, copper ions, fructose 1,6-diphosphate and dietary changes on enzyme activity.大鼠肝脏丙酮酸激酶的调节。预孵育、pH值、铜离子、1,6-二磷酸果糖及饮食变化对酶活性的影响。
Biochem J. 1968 Jul;108(3):427-36. doi: 10.1042/bj1080427.