Lachmann C, Jörg K M, Trinkmann R
Augenklinik der Evangelischen Diakonissenanstalt Karlsruhe-Rüppurr.
Klin Monbl Augenheilkd. 1998 Dec;213(6):326-30. doi: 10.1055/s-2008-1034997.
The aim of the present study was to examine the influence of the topical carbonic anhydrase-II-inhibitor dorzolamide hydrochloride (Trusopt) in regarding to behaviour of intraocular eyepressure after Nd:YAG-laser-capsulotomy.
The study was carried out as a double-blind-test. In a period of nine months, 120 patients underwent Nd:YAG-laser-capsulotomy. One group was given dorzolamide hydrochloride (Trusopt), the other group (placebo) remained without medication. The intraocular pressure was measured before capsulotomy and four hours post-op. For statistical evaluation the t-test of not-associated spot-checks was performed.
The prophylactic use of the topical carbonic anhydrase-II-inhibitor dorzolamide hydrochloride (Trusopt) after nd:YAG-laser-capsulotomy shows a highly significant lowering of intraocular pressure, i.e. 1.09 mm Hg in the average.
It was demonstrated that a single dose of dorzolamide hydrochloride (Trusopt) after Nd:YAG-laser-capsulotomy could lower intraocular pressure significantly. Prophylactical usage of dorzolamide hydrochloride (Trusopt) is a useful method to prevent the increase of intraocular pressure and thus to protect the eye against hazardous damage.
本研究的目的是探讨局部应用碳酸酐酶-II抑制剂盐酸多佐胺（Trusopt）对钕：钇铝石榴石激光晶状体囊切开术后眼压变化的影响。
本研究采用双盲试验。在九个月的时间里，120例患者接受了钕：钇铝石榴石激光晶状体囊切开术。一组给予盐酸多佐胺（Trusopt），另一组（安慰剂组）未用药。在晶状体囊切开术前及术后4小时测量眼压。采用非相关样本的t检验进行统计学评估。
钕：钇铝石榴石激光晶状体囊切开术后预防性使用局部碳酸酐酶-II抑制剂盐酸多佐胺（Trusopt）可显著降低眼压，平均降低1.09 mmHg。
结果表明，钕：钇铝石榴石激光晶状体囊切开术后单次使用盐酸多佐胺（Trusopt）可显著降低眼压。预防性使用盐酸多佐胺（Trusopt）是预防眼压升高从而保护眼睛免受损害的有效方法。
