Anderson R L, Stasior O G
Ophthalmic Surg. 1976 Winter;7(4):28-30.
Self-curing methyl methacrylate has been recently abandoned by some ophthalmic surgeons because of more than 20 deaths associated with its use in orthopedic surgery. The mechanism of cardiovascular collapse noted in orthopedic cases appears to relate to the surgical procedure as well as a direct vasodilation caused by free monomer. There are no reported cardiovascular complications with the facial uses of self-curing methyl methacrylate. Toxicities to this substance are noted. Ophthalmologists should be aware of these problems and their management. Careful preoperative cardiovascular evaluation, intraoperative patient monitoring, and a well-ventilated operating room are recommended with its use. The review finds no evidence to condemn the ophthalmic uses of self-curing methyl methacrylate because of cardiovascular complications. The search for more inert synthetic compounds should continue.
由于在整形外科手术中使用自固化甲基丙烯酸甲酯导致20多人死亡，一些眼科医生最近已不再使用它。整形外科病例中出现的心血管衰竭机制似乎与手术操作以及游离单体引起的直接血管舒张有关。面部使用自固化甲基丙烯酸甲酯未报告有心血管并发症。已注意到该物质的毒性。眼科医生应了解这些问题及其处理方法。建议在使用时进行仔细的术前心血管评估、术中患者监测以及配备通风良好的手术室。该综述未发现因心血管并发症而谴责自固化甲基丙烯酸甲酯眼科用途的证据。对更惰性合成化合物的研究应继续进行。
