Daughton D M, Fortmann S P, Glover E D, Hatsukami D K, Heatley S A, Lichtenstein E, Repsher L, Millatmal T, Killen J D, Nowak R T, Ullrich F, Patil K D, Rennard S I
University of Nebraska Medical Center, Omaha 68198, USA.
Prev Med. 1999 Feb;28(2):113-8. doi: 10.1006/pmed.1998.0391.
This study was undertaken to evaluate the long-term smoking cessation efficacy of varying doses of transdermal nicotine delivery systems 4 to 5 years post-quit day.
A follow-up study was conducted 48 to 62 months after quit day among patients who were enrolled in the Transdermal Nicotine Study Group investigation. The latter study included group smoking cessation counseling and randomized assignment to 21, 14, or 7 mg nicotine patches or placebo patches. Seven of nine smoking cessation research centers participated in the long term follow-up investigation.
The self-reported continuous quit rate among patients originally assigned 21 mg (20.2%) was significantly higher than rates for patients assigned 14 mg (10.4%), 7 mg (11.8%), or placebo patches (7.4%). Log rank survival analysis found no difference in relapse rates after 1 year postcessation. Smokers under age 30 years were significantly less likely to be abstinent at long term follow-up compared to smokers > or = 30 years of age (3 vs 13%, respectively). Mean weight gain in confirmed continuous quitters was 10.1 kg in men and 8.0 kg in women. Of the 63 continuous abstainers surveyed, 30 respondents (48%) reported that they no longer craved cigarettes, and no individual reported daily craving for cigarettes.
Nicotine patch therapy with 21 mg/day patches resulted in a significantly higher long-term continuous abstinence rate compared to lower dose patches and placebo. Relapse rates among the various treatment conditions were similar after 1 year postcessation.
本研究旨在评估戒烟日4至5年后不同剂量经皮尼古丁递送系统的长期戒烟效果。
在参加经皮尼古丁研究组调查的患者戒烟日48至62个月后进行随访研究。后者的研究包括团体戒烟咨询，并随机分配到21毫克、14毫克或7毫克尼古丁贴片或安慰剂贴片组。九个戒烟研究中心中的七个参与了长期随访调查。
最初分配使用21毫克贴片的患者自我报告的持续戒烟率（20.2%）显著高于分配使用14毫克（10.4%）、7毫克（11.8%）或安慰剂贴片的患者。对数秩生存分析发现戒烟后1年的复发率没有差异。与年龄≥30岁的吸烟者相比，30岁以下的吸烟者在长期随访中保持戒烟的可能性显著降低（分别为3%和13%）。确认持续戒烟者的平均体重增加，男性为10.1千克，女性为8.0千克。在接受调查的63名持续戒烟者中，30名受访者（48%）报告他们不再渴望吸烟，且没有个体报告每天渴望吸烟。
与低剂量贴片和安慰剂相比，每天使用21毫克贴片的尼古丁贴片疗法导致显著更高的长期持续戒烟率。戒烟后1年，各种治疗条件下的复发率相似。
