Yamamoto H, Iwase N, Kohno M
Laboratory of Pathology, Kohno Clinical Medicine Research Institute, Tokyo, Japan.
Exp Toxicol Pathol. 1999 Jan;51(1):15-20. doi: 10.1016/S0940-2993(99)80051-7.
A new breed of mouse showing cinnamon-color of hair and osteoarthropathy was born from mouse of the B6C3F1 strain, and was named the BCBC/Y mouse. The incidence and severity of the articular lesions increased with aging, and by 10 to 22 months of age, many mice showed moderate-severe motor paresis with ankylotic changes of the limb joints. Abnormal radiographic changes were observed at many joints with increasing age. There was bone and joint deformity, followed by progressive osteoarthritic changes and ankylosis of the limb joints. Histopathologically, degenerative changes, followed by loosening, fissuring and erosion of the articular cartilage were observed at early stage of articular lesions. Unilateral progressive changes, characterized by joint fusion with abnormal osteophytes, were observed at late stage of articular lesions with aging. For successive breeding to establish a homogeneous strain, generation mice retained the symptoms of the primary mice. Thus, these BCBC/Y mice may be a useful as mode to elucidate the hereditary background and hyperplastic changes of the osteochondrocytes for pathogenesis of the osteoarthropathy.
一种表现出毛发肉桂色和骨关节炎的新型小鼠由B6C3F1品系小鼠繁育而来，被命名为BCBC/Y小鼠。关节病变的发生率和严重程度随年龄增长而增加，到10至22月龄时，许多小鼠出现中度至重度运动性轻瘫，并伴有肢体关节的强直性改变。随着年龄增长，在许多关节处观察到异常的影像学变化。出现了骨骼和关节畸形，随后是渐进性骨关节炎改变和肢体关节强直。组织病理学上，在关节病变早期观察到退行性改变，随后是关节软骨的松动、裂隙和侵蚀。随着年龄增长，在关节病变后期观察到以关节融合和异常骨赘形成为特征的单侧渐进性改变。为了连续繁殖以建立一个同质品系，子代小鼠保留了初代小鼠的症状。因此，这些BCBC/Y小鼠可能是阐明骨关节炎发病机制中骨软骨细胞的遗传背景和增生性变化的有用模型。
